How can leaders wire their organizations to win? Gene Kim explains that work consists of three layers - the objects we work on, the tools we use, and the social connections between people. Successful leaders focus on this third "social circuitry" layer to integrate functions, remove barriers, create independence between teams, amplify weak signals of failure, and practice "slowification" - strategically slowing down to speed up long-term results. He also introduces two other principles - "simplification" and "amplification." Simplification involves breaking down complex problems into manageable parts, while amplification focuses on creating a management system that ensures even the weakest signals of failure are detected and addressed early.